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ASSOCIATE
PROGRAM 3
Isolation and Structure Elucidation of Panama
plants,
marine and terrestrial microorganisms
Bioactives
Associate Program Leader:
William H. Gerwick
Smithsonian Tropical Research Institute (STRI) and
Scripps Institution of Oceanography
This
Associate Program consists of two main components:
| A. |
Bioassay-guided
isolation and characterization of novel terrestrial
plant and endophyte natural products active in tropical
disease, anticancer and agrochemical assays.
Luis
Cubilla-Rios
Laboratory of Tropical Bioorganic
Chemestry, Department of Chemistry,
University of Panama
William
H. Gerwick,
Gerwick Research Lab, Scripps Institution of
Oceanography. Skaggs School of Pharmacy and
Pharmaceutical Sciences, University of California
|
| |
|
| B. |
Bioassay-guided
isolation and characterization of novel marine algal and
cyanobacterial natural products active in tropical
disease, anticancer and agrochemical assays.
Kerry McPhail, College of Pharmacy (Oregon State
University)
Marcy Balunas
|
Aims:
|
-
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To
use bioassay results from AP2 to select and then direct
the chemical isolation of active constituents from pre-fractionated
extracts generated by AP1. |
|
-
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To
determine the molecular structures of new and bioactive
compounds primarily by Nuclear Magnetic Resonance (NMR)
and mass spectral methods. |
|
-
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To
promote student training and to strengthen the
scientific infrastructure in Panama. |
|
-
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To
work in collaboration with industrial partners (Novartis
Pharmaceuticals and Dow AgroSciences) to advance lead
molecules as drugs and/or research biochemicals |
|
-
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To
use any discoveries made as tools for justifying and
directing conservation efforts in Panama. |
Personnel:
|
William
H. Gerwick
|
Leader
|
|
Kerry
McPhail
|
Head
of Laboratory (Oregon State University)
|
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Luis
Cubilla R.
|
PI (University of Panama)
|
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Sergio Martínez
|
Postdoc
(University of Panama)
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Lilia Chérigo
|
PhD.
(University of Panama)
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Edwin
Araúz
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Chemist
(University of Panama)
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Carlos
Ríos
|
Chemist (University of Panama)
|
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Eufemio Moreno
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Student
|
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Itzel Adames
|
Msc Student
(University of Panama)
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Rebecca
Medina
|
Ph.D.
student (O.S.U.)
|
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Luke
Simmons
|
Ph.D.
student (O.S.U.)
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